Very interesting point about "The Pandorica Opens." If you're right that the goal is not to destroy River, but to do something with her once she's been isolated, then it seems to me that whoever's behind it must have been based or able to take refuge outside the universe (since, aside from River and the TARDIS locked in an eternal moment, everything in the universe was being destroyed). Handily, we have "The Doctor's Wife" to show us that travel outside the universe is possible... also, I wonder whether parallel universes such as Pete's World were affected by the explosion.
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Very interesting point about "The Pandorica Opens." If you're right that the goal is not to destroy River, but to do something with her once she's been isolated, then it seems to me that whoever's behind it must have been based or able to take refuge outside the universe (since, aside from River and the TARDIS locked in an eternal moment, everything in the universe was being destroyed). Handily, we have "The Doctor's Wife" to show us that travel outside the universe is possible... also, I wonder whether parallel universes such as Pete's World were affected by the explosion.